Diethyl Ether → HCID 86755925, 화합물

HRID 365426노트

반응식

HRID 365426 반응식
C(OC(=O)[NH:7][C@H:8]([C:22](=[O:24])[NH2:23])[CH2:9][CH2:10][CH2:11][CH2:12][NH:13][C:14]([O:16][CH2:17][C:18]([Cl:21])([Cl:20])[Cl:19])=[O:15])(C)(C)C.C(OCC)C>Cl.C(OCC)(=O)C>[ClH:19].[Cl:19][C:18]([Cl:20])([Cl:21])[CH2:17][O:16][C:14](=[O:15])[NH:13][CH2:12][CH2:11][CH2:10][CH2:9][C@H:8]([NH2:7])[C:22](=[O:24])[NH2:23]

참가 물질

5

반응물 2

HCID 3283Diethyl EtherHCID 53863840HCID 53863840, 화합물

생성물 1

HCID 86755925HCID 86755925, 화합물수율 181.7%

시약·촉매·용매 2

HCID 313Hydrochloric Acid용매HCID 8857Ethyl Acetate용매

실험 절차

[(1S)-1-carbamoyl-5-(2,2,2-trichloroethoxycarbonylamino)pentyl]carbamic acid tert butyl ester (39.5 g; 94 mmole) was dissolved in a solution of hydrogen chloride in ethyl acetate (1.5 M, 300 ml) and stirred for 30 min. Diethyl ether (300 ml) was added and the precipitate was filtered and dried to afford 30.5 g of ((5S)-5-amino-5-carbamoylpentyl)carbamic acid 2,2,2-trichloroethyl ester hydrochloride.

후처리

  1. filtrationthe precipitate was filtered
  2. customdried

출처 및 근거

ORD 기록
ord-51ce729462d246598af54180cc2f29e2
출처 데이터셋
uspto-grants-2000_10
특허 번호
US06127341

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