Methanol → Pyridine-3,5-dicarboxylic acid methyl ester hydrochloride

HRID 365437

반응식

HRID 365437 반응식
[N:1]1[CH:6]=[C:5]([C:7]([OH:9])=[O:8])[CH:4]=[C:3]([C:10]([OH:12])=[O:11])[CH:2]=1.S(Cl)([Cl:15])=O.[CH3:17]O>>[ClH:15].[CH3:17][O:8][C:7]([C:5]1[CH:6]=[N:1][CH:2]=[C:3]([C:10]([OH:12])=[O:11])[CH:4]=1)=[O:9]

참가 물질

4

반응물 3

HCID 887MethanolHCID 103663,5-Pyridinedicarboxylic acidHCID 24386Thionyl Chloride

생성물 1

HCID 70274642Pyridine-3,5-dicarboxylic acid methyl ester hydrochloride

실험 절차

Pyridine-3,5-dicarboxylic acid (5.00 g, 29.9 mmol) was stirred in CH3OH (100 mL), cooled in an ice bath, and treated dropwise with thionyl chloride (17.45 mL, 239.2 mmol). After 0.5 hr, the reaction mixture was refluxed for 48 hrs. Concentration to dryness gave the title compound as an off-white solid.

후처리

  1. temperaturecooled in an ice bath
  2. temperaturethe reaction mixture was refluxed for 48 hrs
  3. concentrationConcentration to dryness

출처 및 근거

ORD 기록
ord-1b62a4aa5e3545ef8cc070eb914f7418
출처 데이터셋
uspto-grants-2000_10
특허 번호
US06127366

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