Thionyl Chloride → 3-(3-Pyridyl)acryloyl chloride hydrochloride

HRID 36548

반응식

HRID 36548 반응식
[N:1]1[CH:6]=[CH:5][CH:4]=[C:3]([CH:7]=[CH:8][C:9]([OH:11])=O)[CH:2]=1.S(Cl)([Cl:14])=O>C1C=CC=CC=1>[ClH:14].[N:1]1[CH:6]=[CH:5][CH:4]=[C:3]([CH:7]=[CH:8][C:9]([Cl:14])=[O:11])[CH:2]=1

참가 물질

4

반응물 2

HCID 24386Thionyl ChlorideHCID 1019843-(3-Pyridinyl)-2-propenoic acid

생성물 1

HCID 713600273-(3-Pyridyl)acryloyl chloride hydrochloride

시약·촉매·용매 1

HCID 241Benzene용매

실험 절차

67 ml of benzene was added to 10 grams of 3-(3-pyridyl)-acrylic acid. 8.1 ml of thionyl chloride was added dropwise slowly thereto at ambient temperature. The temperature was elevated to 70° C. and the heating was continued until foaming ceased. Benzene and thionyl chloride were distilled off and the residue was dried thoroughly under reduced pressure.

후처리

  1. customat ambient temperature
  2. customwas elevated to 70° C.
  3. distillationBenzene and thionyl chloride were distilled off
  4. customthe residue was dried thoroughly under reduced pressure

출처 및 근거

ORD 기록
ord-c47a2810ac0e4dcd8f71084b2669a25f
출처 데이터셋
uspto-grants-1995_05
특허 번호
US05415780

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