1,2-Bis(chloromethyl)benzene → N-(2-chloromethylbenzyl)phthalimide

반응식

Cl[CH2:2][C:3]1[C:4]([CH2:9][Cl:10])=[CH:5][CH:6]=[CH:7][CH:8]=1.[C:11]1(=[O:21])[NH:15][C:14](=[O:16])[C:13]2=[CH:17][CH:18]=[CH:19][CH:20]=[C:12]12.[K]>>[C:11]1(=[O:21])[N:15]([CH2:2][C:3]2[C:4]([CH2:9][Cl:10])=[CH:5][CH:6]=[CH:7][CH:8]=2)[C:14](=[O:16])[C:13]2=[CH:17][CH:18]=[CH:19][CH:20]=[C:12]12

참가 물질

반응물 2

HCID 119191,2-Bis(chloromethyl)benzene

HCID 24194345Phthalimide potassium salt

생성물 1

HCID 57925620N-(2-chloromethylbenzyl)phthalimide

반응 조건

온도: 50 °C

실험 절차

A mixture of α,α'-dichloroxylene (8.75 g, 50 mmol) and potassium phthalimide (5.6 g, 30 mmol) was heated to 50° C. for 24 h. Then the reaction mixture was concentrated in vacuo, dissolved in ethyl acetate and, after usual work-up, the desired compound was obtained by flash chromatography on silica gel (ethyl acetate:hexane; 15:85) (6 g, 65%).

후처리

concentrationThen the reaction mixture was concentrated in vacuo
dissolutiondissolved in ethyl acetate

출처 및 근거

ORD 기록: ord-83c234a702b148d187820f5614fe44cc
출처 데이터셋: uspto-grants-1995_05
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US05416076

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