3-Bromoaniline → HCID 22225739, 화합물

HRID 366510

반응식

HRID 366510 반응식
[Si:1]([O:8][CH2:9][CH2:10][C:11]#[CH:12])([C:4]([CH3:7])([CH3:6])[CH3:5])([CH3:3])[CH3:2].Br[C:14]1[CH:15]=[C:16]([CH:18]=[CH:19][CH:20]=1)[NH2:17]>C(N)CCC.C1C=CC([P]([Pd]([P](C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)([P](C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)[P](C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)=CC=1>[O:8]([CH2:9][CH2:10][C:11]#[C:12][C:14]1[CH:20]=[CH:19][CH:18]=[C:16]([NH2:17])[CH:15]=1)[Si:1]([C:4]([CH3:5])([CH3:6])[CH3:7])([CH3:3])[CH3:2]

참가 물질

5

반응물 2

HCID 115623-BromoanilineHCID 4304567(But-3-yn-1-yloxy)(tert-butyl)dimethylsilane

생성물 1

HCID 22225739HCID 22225739, 화합물

시약·촉매·용매 2

HCID 178418397HCID 178418397, 화합물촉매HCID 8007Butylamine용매

실험 절차

A mixture of 1-(t-butyldimethylsilyloxy)-3-butyne (10 mmol) and m-bromoaniline (10 mmol) in n-butylamine (50 mL) under a nitrogen atmosphere is treated with tetrakis(triphenylphosphine)palladium (0) (0.17 g) and then heated to reflux for 18 hr. After removing the solvent in vacuo, the residue is dissolved in CH2Cl2 and washed with saturated NaHCO3. The combined organic solution is dried over magnesium sulfate, filtered and evaporated to give the above described silyl protected adduct.

후처리

  1. temperatureheated
  2. temperatureto reflux for 18 hr
  3. customAfter removing the solvent in vacuo
  4. dissolutionthe residue is dissolved in CH2Cl2
  5. washwashed with saturated NaHCO3
  6. dry with materialThe combined organic solution is dried over magnesium sulfate
  7. filtrationfiltered
  8. customevaporated
  9. customto give the

출처 및 근거

ORD 기록
ord-2bffa424f5384ed486a6d8f0e064a4a9
출처 데이터셋
uspto-grants-2000_10
특허 번호
US06130234

연결된 노트

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