Potassium Carbonate → 3-n-Decyl-3-azabicyclo[3.1.0]hexane-2,4-dione

HRID 366531

반응식

HRID 366531 반응식
I[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH3:11].[CH:12]12[CH2:17][CH:16]1[C:15](=[O:18])[NH:14][C:13]2=[O:19].C(=O)([O-])[O-].[K+].[K+]>[Br-].C([N+](CCCC)(CCCC)CCCC)CCC.ClCCl>[CH2:2]([N:14]1[C:15](=[O:18])[CH:16]2[CH:12]([CH2:17]2)[C:13]1=[O:19])[CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH3:11]

참가 물질

6

반응물 3

HCID 11430Potassium CarbonateHCID 163141-IododecaneHCID 37200533-Azabicyclo[3.1.0]hexane-2,4-dione

생성물 1

HCID 232899843-n-Decyl-3-azabicyclo[3.1.0]hexane-2,4-dione

시약·촉매·용매 2

HCID 74236Tetrabutylammonium Bromide촉매HCID 6344Dichloromethane용매

실험 절차

1-Iododecane (1.21 g) was added to a stirred mixture of 3-azabicyclo[3.1.0]hexane-2,4 dione (0.5 g), potassium carbonate (0.62 g) and tetrabutylammonium bromide (1.45 g) in dichloromethane (50 ml) at room temperature and the resulting mixture was stirred for 24 hours. The mixture was filtered and the filtrate was then washed with water (2×100 ml), dried (MgSO4) and evaporated in vacuo to give a brown oil. The oil was purified by column chromatography on silica gel (100 g) using hexane as eluant. Combination and evaporation of the appropriate fractions gave the title compound as a colourless oil.

후처리

  1. filtrationThe mixture was filtered
  2. washthe filtrate was then washed with water (2×100 ml)
  3. dry with materialdried (MgSO4)
  4. customevaporated in vacuo
  5. customto give a brown oil
  6. customThe oil was purified by column chromatography on silica gel (100 g)
  7. customCombination and evaporation of the appropriate fractions

출처 및 근거

ORD 기록
ord-b6791d355ab8451faf9e7b93158ea257
출처 데이터셋
uspto-grants-2000_10
특허 번호
US06130241

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