Sodium hydride → 3-(2-Ethylhex-1-yl)-3-azabicyclo[3.1.0]hexane-2,4-dione

HRID 366536

반응식

HRID 366536 반응식
[H-].[Na+].[CH:3]12[CH2:8][CH:7]1[C:6](=[O:9])[NH:5][C:4]2=[O:10].Br[CH2:12][CH:13]([CH2:18][CH3:19])[CH2:14][CH2:15][CH2:16][CH3:17]>CN(C)C=O.O>[CH2:18]([CH:13]([CH2:14][CH2:15][CH2:16][CH3:17])[CH2:12][N:5]1[C:6](=[O:9])[CH:7]2[CH:3]([CH2:8]2)[C:4]1=[O:10])[CH3:19]

참가 물질

6

반응물 3

HCID 24758Sodium hydrideHCID 868042-Ethylhexyl bromideHCID 37200533-Azabicyclo[3.1.0]hexane-2,4-dione

생성물 1

HCID 232899853-(2-Ethylhex-1-yl)-3-azabicyclo[3.1.0]hexane-2,4-dione

시약·촉매·용매 2

HCID 962Water용매HCID 6228Dimethylformamide용매

실험 절차

Sodium hydride (0.11 g) was added to a solution of 3-azabicyclo[3.1.0]hexane-2,4-dione (0.3 g) and 1-bromo-2-ethylhexane (0.52 g) in dimethylformamide (5 ml) and the resulting mixture was stirred at room temperature under a nitrogen atmosphere for 16 hours. The mixture was diluted with water (15 ml) and then extracted with toluene (20 ml). The organic extract was washed with water (15 ml), dried (MgSO4) and evaporated in vacuo. The residue was purified by Kugelrohr distillation (boiling point 140-160° C. @ 0.1 mmHg) to give the title compound as a colourless oil.

후처리

  1. extractionextracted with toluene (20 ml)
  2. extractionThe organic extract
  3. washwas washed with water (15 ml)
  4. dry with materialdried (MgSO4)
  5. customevaporated in vacuo
  6. distillationThe residue was purified by Kugelrohr distillation (boiling point 140-160° C. @ 0.1 mmHg)

출처 및 근거

ORD 기록
ord-ebc6f14a1fce43f5b81d0c715a8f84cb
출처 데이터셋
uspto-grants-2000_10
특허 번호
US06130241

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