Sodium Hydroxide → 6-Benzyl-octahydropyrrolo[3,4-b][1,4]oxazine

HRID 36657노트

반응식

HRID 36657 반응식
[CH2:1]([N:8]1[CH2:12][CH:11](O)[CH:10]([NH:14][CH2:15][CH2:16][OH:17])[CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[OH-].[Na+]>S(=O)(=O)(O)O.O>[CH2:1]([N:8]1[CH2:12][CH:11]2[CH:10]([NH:14][CH2:15][CH2:16][O:17]2)[CH2:9]1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

참가 물질

5

반응물 2

HCID 14798Sodium HydroxideHCID 19969797HCID 19969797, 화합물

생성물 1

HCID 150699806-Benzyl-octahydropyrrolo[3,4-b][1,4]oxazine

시약·촉매·용매 2

HCID 962Water용매HCID 1118Sulfuric Acid용매

실험 절차

15.6 g (66mmol) of 1-benzyl-4-hydroxy-3-(2-hydroxyethylamino)-pyrrolidine are heated under reflux in a mixture of 60 ml of concentrated sulphuric acid and 20 ml of water for 6 hours. The mixture is rendered alkaline with concentrated sodium hydroxide solution, the sodium sulphate which has precipitated is filtered off with suction and the filtrate is extracted with chloroform. The extract is dried over potassium carbonate and concentrated and the residue is distilled.

후처리

  1. customthe sodium sulphate which has precipitated
  2. filtrationis filtered off with suction
  3. extractionthe filtrate is extracted with chloroform
  4. dry with materialThe extract is dried over potassium carbonate
  5. concentrationconcentrated
  6. distillationthe residue is distilled

출처 및 근거

ORD 기록
ord-fbb9da8152d3432bb09a0df0f86dab43
출처 데이터셋
uspto-grants-1995_05
특허 번호
US05416096

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