Ethyl chloroformate → Ethyl 2,2-dimethoxyethylcarbamate

HRID 36663

반응식

HRID 36663 반응식
Cl[C:2]([O:4][CH2:5][CH3:6])=[O:3].[CH3:7][O:8][CH:9]([O:12][CH3:13])[CH2:10][NH2:11].[OH-].[Na+]>C1(C)C=CC=CC=1.O>[CH3:7][O:8][CH:9]([O:12][CH3:13])[CH2:10][NH:11][C:2](=[O:3])[O:4][CH2:5][CH3:6]

참가 물질

6

반응물 3

HCID 10928Ethyl chloroformateHCID 14798Sodium HydroxideHCID 89728Aminoacetaldehyde dimethyl acetal

생성물 1

HCID 10921057Ethyl 2,2-dimethoxyethylcarbamate

시약·촉매·용매 2

HCID 962Water용매HCID 1140Toluene용매

실험 절차

214 g (2 mol) of ethyl chloroformate are added dropwise to 214 g (2 mol) of aminoacetaldehyde dimethyl acetal in 1 l of toluene and 90 g of NaOH in 500 ml of water at 10° C. The mixture is stirred at room temperature for a further 2 hours and the aqueous phase is separated off, saturated with sodium chloride and extracted with toluene. The toluene solutions are dried over magnesium sulphate and concentrated and the residue is distilled.

후처리

  1. customthe aqueous phase is separated off, saturated with sodium chloride
  2. extractionextracted with toluene
  3. dry with materialThe toluene solutions are dried over magnesium sulphate
  4. concentrationconcentrated
  5. distillationthe residue is distilled

출처 및 근거

ORD 기록
ord-9d97b7ac3ac0435c8feda74e2c76dc3b
출처 데이터셋
uspto-grants-1995_05
특허 번호
US05416096

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