Water → N-(4-iodophenyl)-2-methylpropanamide

HRID 3667

반응식

HRID 3667 반응식
[I:1][C:2]1[CH:8]=[CH:7][C:5]([NH2:6])=[CH:4][CH:3]=1.N1C=CC=CC=1.[C:15](Cl)(=[O:19])[CH:16]([CH3:18])[CH3:17].O>C(#N)C>[I:1][C:2]1[CH:8]=[CH:7][C:5]([NH:6][C:15](=[O:19])[CH:16]([CH3:18])[CH3:17])=[CH:4][CH:3]=1

참가 물질

6

반응물 4

HCID 962WaterHCID 1049PyridineHCID 108934-IodoanilineHCID 62325Isobutyryl chloride2회

생성물 1

HCID 836020N-(4-iodophenyl)-2-methylpropanamide수율 97.4%

시약·촉매·용매 1

HCID 6342Acetonitrile용매

실험 절차

To a dispersion of p-iodoaniline (219.0 g, 1 mol) in acetonitrile(1000 ml) was added pyridine (81.0 ml, 1 mol). Isobutyryl chloride (100.5 ml, 1 mol) was added dropwise to the mixture over 1 hour in an ice bath. The mixture was further stirred for one hour following the addition of isobutyryl chloride and to the mixture was added water (3000 ml). Precipitated crystalline solids were collected by filtration to give N-(4-iodophenyl)isobutyramide (281.7 g, Yield: 97%).

후처리

  1. filtrationPrecipitated crystalline solids were collected by filtration

출처 및 근거

ORD 기록
ord-1e9f35d9308c4443ac4377883641dd28
출처 데이터셋
uspto-grants-1998_03
특허 번호
US05734063

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