Ethyl chloroformate → N-(1,1-dimethoxyprop-2-yl)urethane

HRID 36683

반응식

HRID 36683 반응식
Cl[C:2]([O:4][CH2:5][CH3:6])=[O:3].[CH3:7][O:8][CH:9]([O:13][CH3:14])[CH:10]([NH2:12])[CH3:11].[OH-].[Na+]>C1(C)C=CC=CC=1.O>[CH3:7][O:8][CH:9]([O:13][CH3:14])[CH:10]([NH:12][C:2]([O:4][CH2:5][CH3:6])=[O:3])[CH3:11]

참가 물질

6

반응물 3

HCID 10928Ethyl chloroformateHCID 14798Sodium HydroxideHCID 936582,2-Dimethoxy-1-methylethylamine

생성물 1

HCID 15069987N-(1,1-dimethoxyprop-2-yl)urethane

시약·촉매·용매 2

HCID 962Water용매HCID 1140Toluene용매

실험 절차

80 g (0.73 mol) of ethyl chloroformate are added dropwise to 86.2 g (0.72 mol) of 2-aminopropionaldehyde dimethyl acetal in 350 ml of toluene and 32 g (0.8 mol) of NaOH in 300 ml of water. The mixture is stirred at room temperature for a further 2 hours, the organic phase is separated off, the aqueous phase is extracted with toluene and the toluene solutions are dried over K2CO3. The solution is concentrated and the residue is distilled.

후처리

  1. customthe organic phase is separated off
  2. extractionthe aqueous phase is extracted with toluene
  3. dry with materialthe toluene solutions are dried over K2CO3
  4. concentrationThe solution is concentrated
  5. distillationthe residue is distilled

출처 및 근거

ORD 기록
ord-acd54b968634414ab260eeadb9f96832
출처 데이터셋
uspto-grants-1995_05
특허 번호
US05416096

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