Benzylamine → 1-Benzyl-2,5-dihydropyrrole

HRID 366867

반응식

HRID 366867 반응식
[CH3:1]/[CH:2]=[CH:3]\[CH3:4].[CH2:5]([NH2:12])[C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1>C1(C)C=CC=CC=1>[CH2:5]([N:12]1[CH2:4][CH:3]=[CH:2][CH2:1]1)[C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1

참가 물질

4

반응물 2

HCID 7504BenzylamineHCID 5287573cis-2-BUTENE

생성물 1

HCID 5615061-Benzyl-2,5-dihydropyrrole수율 89.5%

시약·촉매·용매 1

HCID 1140Toluene용매

실험 절차

To a solution of 60.0 g of the cis-2-butene derivative solution prepared in Example 1 and 250 g of toluene in a round flask reactor, 171.7 g (1.6 mol) of benzylamine was added dropwise with stirring for 30 min. at ambient temperature. After 2 hours of stirring, the crystallized solid was removed by filtration; 42.0 g of 35% HCl (aq) was added to the filtrate, and then excess benzylamine hydrochloride was removed by filtration or extraction. After the solvent was evaporated under reduced pressure, 57.0 g of 1-benzyl-3-pyrroline (yield 89.5%) was obtained.

후처리

  1. stirringAfter 2 hours of stirring
  2. customthe crystallized solid was removed by filtration
  3. addition42.0 g of 35% HCl (aq) was added to the filtrate
  4. customexcess benzylamine hydrochloride was removed by filtration or extraction
  5. customAfter the solvent was evaporated under reduced pressure

출처 및 근거

ORD 기록
ord-b16b84cc9b0e4e38bfb16f8ea36576a5
출처 데이터셋
uspto-grants-2000_10
특허 번호
US06130338

연결된 노트

불러오는 중…