5-Bromoindole → 5-bromo-3-(1-methyl-1,2,3,6-tetrahydro-4-pyridinyl)-1H-indole

HRID 367369노트

반응식

HRID 367369 반응식
[Br:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][CH:6]=[CH:5]2.[CH3:11][N:12]1[CH2:17][CH2:16][C:15](=O)[CH2:14][CH2:13]1.N1CCCC1>C(O)C>[Br:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][CH:6]=[C:5]2[C:15]1[CH2:16][CH2:17][N:12]([CH3:11])[CH2:13][CH:14]=1

참가 물질

5

반응물 3

HCID 249055-BromoindoleHCID 31268PyrrolidineHCID 740491-Methyl-4-piperidone

생성물 1

HCID 149732085-bromo-3-(1-methyl-1,2,3,6-tetrahydro-4-pyridinyl)-1H-indole수율 76%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

5-Bromo-1H-indole (4.31 g, 22 mmol), 1-methyl-4-piperidone (2.46 mL, 20 mmol) and pyrrolidine (17 mL, 200 mmol) were mixed in ethanol (30 mL) and refluxed for 72 hours. The mixture was cooled to room temperature and the resulting solid, collected by filtration, washed with methanol and dried to provide the title compound as a white solid (4.40 g, 76%). mp>230° C., dec.

후처리

  1. temperaturerefluxed for 72 hours
  2. filtrationthe resulting solid, collected by filtration
  3. washwashed with methanol
  4. customdried

출처 및 근거

ORD 기록
ord-b7cd3a6acffc4baeb09b2ac3fbb58cd8
출처 데이터셋
uspto-grants-2000_10
특허 번호
US06133287

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