Hydrochloric Acid → HCID 23288129, 화합물

HRID 367385노트

반응식

HRID 367385 반응식
[CH3:1][N:2]1[CH2:7][CH:6]=[C:5]([C:8]2[C:16]3[C:11](=[CH:12][CH:13]=[C:14]([C:17]([F:20])([F:19])[F:18])[CH:15]=3)[NH:10][CH:9]=2)[CH2:4][CH2:3]1.[F:21][C:22]1[CH:27]=[CH:26][C:25]([S:28]([Cl:31])(=[O:30])=[O:29])=[CH:24][CH:23]=1.Cl>>[ClH:31].[F:21][C:22]1[CH:27]=[CH:26][C:25]([S:28]([N:10]2[C:11]3[C:16](=[CH:15][C:14]([C:17]([F:20])([F:18])[F:19])=[CH:13][CH:12]=3)[C:8]([C:5]3[CH2:4][CH2:3][N:2]([CH3:1])[CH2:7][CH:6]=3)=[CH:9]2)(=[O:30])=[O:29])=[CH:24][CH:23]=1

참가 물질

4

반응물 3

HCID 313Hydrochloric Acid2회HCID 95884-Fluorobenzenesulfonyl chlorideHCID 232880753-(1,2,3,6-Tetrahydro-1-methyl-4-pyridinyl)-5-(trifluoromethyl)-1H-indole

생성물 1

HCID 23288129HCID 23288129, 화합물

실험 절차

(15.0 mg, 44%); from 3-(1-methyl-1,2,3,6-tetrahydro-4-pyridinyl)-5-trifluoromethyl-1H-indole (Example 4i, 20 mg, 0.071 mmol) and 4-fluorophenylsulfonyl chloride (20.8 mg, 0.107 mmol). HRMS-FAB+ for C21H18N2O2SF4.HCl, calculated MH+ (--HCl): 439.11035; found: 439.10807.

출처 및 근거

ORD 기록
ord-d57e0e3672444331b241faf80791fada
출처 데이터셋
uspto-grants-2000_10
특허 번호
US06133287

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