Azobisisobutyronitrile → 1-[5-O-(t-butyldiphenylsilyl)-2,3-dideoxy-2,2-di(phenylthio)-alpha-D-glycero-pentofuranosyl]uracil

HRID 36759노트

반응식

HRID 36759 반응식
[Si:1]([O:18][CH2:19][C@H:20]1[O:24][C@@H:23]([N:25]2[CH:32]=[CH:31][C:29](=[O:30])[NH:28][C:26]2=[O:27])[C:22]([S:40][C:41]2[CH:46]=[CH:45][CH:44]=[CH:43][CH:42]=2)([S:33][C:34]2[CH:39]=[CH:38][CH:37]=[CH:36][CH:35]=2)[CH2:21]1)([C:14]([CH3:17])([CH3:16])[CH3:15])([C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.CC(N=NC(C#N)(C)C)(C#N)C>C1C=CC=CC=1>[Si:1]([O:18][CH2:19][C@H:20]1[O:24][C@H:23]([N:25]2[CH:32]=[CH:31][C:29](=[O:30])[NH:28][C:26]2=[O:27])[C:22]([S:40][C:41]2[CH:46]=[CH:45][CH:44]=[CH:43][CH:42]=2)([S:33][C:34]2[CH:39]=[CH:38][CH:37]=[CH:36][CH:35]=2)[CH2:21]1)([C:14]([CH3:15])([CH3:16])[CH3:17])([C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1)[C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1

참가 물질

4

반응물 2

HCID 6547AzobisisobutyronitrileHCID 111150361-[5-O-(t-butyldiphenylsilyl)-2,3-dideoxy-2,2-di(phenylthio)-beta-D-glycero-pentofuranosyl]uracil

생성물 1

HCID 152169961-[5-O-(t-butyldiphenylsilyl)-2,3-dideoxy-2,2-di(phenylthio)-alpha-D-glycero-pentofuranosyl]uracil

시약·촉매·용매 1

HCID 241Benzene용매

실험 절차

To a solution prepared by dissolving 7 mg (0.10 mmol) of 1-[5-O-(t-butyldiphenylsilyl)-2,3-dideoxy-2,2-di(phenylthio)-β-D-glycero-pentofuranosyl]uracil prepared in step (3) in 10 ml of anhydrous benzene, 150 μl (0.57 mmol) of hydrogenated tributyl tin and 10 mg of azobisisobutylonitrile were added, followed by subjecting the resultant solution to a reflux under heating for 48 hours under an argon gas atmosphere. After completion of the reaction, a low boiling point substances were removed by distillation under a reduced pressure so as to obtain a residue.

후처리

  1. customTo a solution prepared
  2. additionwere added
  3. temperaturea reflux
  4. temperatureunder heating for 48 hours under an argon gas atmosphere
  5. customAfter completion of the reaction
  6. customa low boiling point substances were removed by distillation under a reduced pressure so as
  7. customto obtain a residue

출처 및 근거

ORD 기록
ord-f798647032db4cd8b9a00f3604fcfd6d
출처 데이터셋
uspto-grants-1995_05
특허 번호
US05416204

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