3-Cyanopyridine → 4-Chloro-2-(pyridin-3-yl)-5-methyl-thieno-[2,3-d]-pyrimidine

HRID 367767

반응식

HRID 367767 반응식
[C:1]([C:3]1[CH:4]=[N:5][CH:6]=[CH:7][CH:8]=1)#[N:2].[NH2:9][C:10]1[S:11][CH:12]=[C:13]([CH3:20])[C:14]=1[C:15](OCC)=O.O=P(Cl)(Cl)[Cl:23]>>[Cl:23][C:15]1[C:14]2[C:13]([CH3:20])=[CH:12][S:11][C:10]=2[N:9]=[C:1]([C:3]2[CH:4]=[N:5][CH:6]=[CH:7][CH:8]=2)[N:2]=1

참가 물질

4

반응물 3

HCID 793-CyanopyridineHCID 24813Phosphorus oxychlorideHCID 521132Ethyl 2-amino-4-methylthiophene-3-carboxylate

생성물 1

HCID 184600144-Chloro-2-(pyridin-3-yl)-5-methyl-thieno-[2,3-d]-pyrimidine

실험 절차

With the procedure of Example 477, the reaction of 3-cyanopyridine and 2-amino-4-methyl-3-ethoxycarbonyl-thiophene, and the subsequent reaction with POCl3 yields 4-chloro-2-(pyridin-3-yl)-5-methyl-thieno-[2,3-d]-pyrimidine.

출처 및 근거

ORD 기록
ord-934c29e32a8e4e53ab8e9cd8243e5b7e
출처 데이터셋
uspto-grants-2000_10
특허 번호
US06133271

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