Phosphorus oxychloride → 4-Chloro-2-(isoxazol-5-yl)-5-methyl-thieno-[2,3-d]-pyrimidine

HRID 367773

반응식

HRID 367773 반응식
[C:1]([C:3]1[O:7][N:6]=[CH:5][CH:4]=1)#[N:2].[NH2:8][C:9]1[S:10][CH:11]=[C:12]([CH3:19])[C:13]=1[C:14](OCC)=O.O=P(Cl)(Cl)[Cl:22]>>[Cl:22][C:14]1[C:13]2[C:12]([CH3:19])=[CH:11][S:10][C:9]=2[N:8]=[C:1]([C:3]2[O:7][N:6]=[CH:5][CH:4]=2)[N:2]=1

참가 물질

4

반응물 3

HCID 24813Phosphorus oxychlorideHCID 521132Ethyl 2-amino-4-methylthiophene-3-carboxylateHCID 112287641,2-Oxazole-5-carbonitrile

생성물 1

HCID 184601204-Chloro-2-(isoxazol-5-yl)-5-methyl-thieno-[2,3-d]-pyrimidine

실험 절차

With the procedure of Example 477, the reaction of 5-cyanoisoxazole and 2-amino-4-methyl-3-ethoxycarbonyl-thiophene, and the subsequent reaction with POCl3 yields 4-chloro-2-(isoxazol-5-yl)-5-methyl-thieno-[2,3-d]-pyrimidine

출처 및 근거

ORD 기록
ord-5c795977b6fc41baba12e03211b958ed
출처 데이터셋
uspto-grants-2000_10
특허 번호
US06133271

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