Phosphorus oxychloride → 4-Chloro-2-(isoxazol-5-yl)-6-ethyl-thieno-[2,3-d]-pyrimidine

반응식

[C:1]([C:3]1[O:7][N:6]=[CH:5][CH:4]=1)#[N:2].[NH2:8][C:9]1[S:10][C:11]([CH2:19][CH3:20])=[CH:12][C:13]=1[C:14](OCC)=O.O=P(Cl)(Cl)[Cl:23]>>[Cl:23][C:14]1[C:13]2[CH:12]=[C:11]([CH2:19][CH3:20])[S:10][C:9]=2[N:8]=[C:1]([C:3]2[O:7][N:6]=[CH:5][CH:4]=2)[N:2]=1

참가 물질

반응물 3

HCID 24813Phosphorus oxychloride

HCID 78263Ethyl 2-amino-5-ethyl-3-thenoate

HCID 112287641,2-Oxazole-5-carbonitrile

생성물 1

HCID 184600984-Chloro-2-(isoxazol-5-yl)-6-ethyl-thieno-[2,3-d]-pyrimidine

실험 절차

With the procedure of Example 477, the reaction of 5-cyanoisoxazole and 2-amino-5-ethyl-3-ethoxycarbonyl-thiophene, and the subsequent reaction with POCl3 yields 4-chloro-2-(isoxazol-5-yl)-6-ethyl-thieno-[2,3-d]-pyrimidine

출처 및 근거

ORD 기록: ord-9738ace19e054fac9d37052414aa8e5a
출처 데이터셋: uspto-grants-2000_10
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US06133271

반응 노트

불러오는 중…