반응식
[CH2:1](O)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH3:17].P(Br)(Br)[Br:20]>>[Br:20][CH2:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH3:17]참가 물질
3
반응 조건
- 온도
- 60 °C
실험 절차
1-Heptadecanol (10 g, 39.1 mmol) was placed in a dry 25 ml round bottom flask attached to a reflux condenser and heated to 60° C. under a nitrogen atmosphere. Phosphorous tribromide (10 g, 39.1 mmol) was added dropwise and the resulting solution was stirred for 48 h. The reaction mixture was then cooled in an ice bath and quenched with a saturated solution of NaHCO3 (10 ml). The aqueous layer was extracted with ether (4×10 ml). The combined organic layers were dried over MgSO4, filtered and concentrated. The crude residue was flash chromatographed (hexanes) to afford 7.2 g (57%) of 1-bromoheptadecane as a colorless oil.
후처리
- customattached to a reflux condenser
- temperatureThe reaction mixture was then cooled in an ice bath
- customquenched with a saturated solution of NaHCO3 (10 ml)
- extractionThe aqueous layer was extracted with ether (4×10 ml)
- dry with materialThe combined organic layers were dried over MgSO4
- filtrationfiltered
- concentrationconcentrated
- customchromatographed (hexanes)
출처 및 근거
- ORD 기록
- ord-c8efaeb97bb741248fb4d614915fbb70
- 출처 데이터셋
- uspto-grants-2000_10
- 특허 번호
- US06133313
연결된 노트
불러오는 중…