Acetonitrile → 4-(t-Butylamino)-2,3,5,6-tetrafluoropyridine

HRID 368418

반응식

HRID 368418 반응식
C(#N)C.[F:4][C:5]1[N:10]=[C:9]([F:11])[C:8]([F:12])=[C:7](F)[C:6]=1[F:14].[C:15]([NH2:19])([CH3:18])([CH3:17])[CH3:16]>C(Cl)(Cl)Cl>[C:15]([NH:19][C:7]1[C:8]([F:12])=[C:9]([F:11])[N:10]=[C:5]([F:4])[C:6]=1[F:14])([CH3:18])([CH3:17])[CH3:16]

참가 물질

5

반응물 3

HCID 6342AcetonitrileHCID 6385Tert-ButylamineHCID 69690Pentafluoropyridine

생성물 1

HCID 221211594-(t-Butylamino)-2,3,5,6-tetrafluoropyridine수율 71.4%

시약·촉매·용매 1

HCID 6212Chloroform용매

실험 절차

To 100 ml of acetonitrile was added 24.5 g of pentafluoropyridine, and the mixture was stirred in an ice bath simultaneously with the dropwise addition of 30 g of t-butylamine. When the mixture warmed to room temperature, 150 ml of chloroform was added, and the mixture was washed twice with 800 ml of distilled water. The chloroform layer was dried over anhydrous magnesium sulfate and concentrated under reduced pressure to obtain 23 g of the title compound as a pale yellow oil.

후처리

  1. washthe mixture was washed twice with 800 ml of distilled water
  2. dry with materialThe chloroform layer was dried over anhydrous magnesium sulfate
  3. concentrationconcentrated under reduced pressure

출처 및 근거

ORD 기록
ord-c491565e5fa549ff8464593fe08b775f
출처 데이터셋
uspto-grants-2000_10
특허 번호
US06133284

연결된 노트

불러오는 중…