2-Chloro-N,N-diethylbenzamide → n,n-Diethyl-2-chloro-6-[tris(1-methylethyl)silyl]benzamide

HRID 368585

반응식

HRID 368585 반응식
[CH2:1]([N:3]([CH2:13][CH3:14])[C:4](=[O:12])[C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][C:6]=1[Cl:11])[CH3:2].[CH:15]([Si:18](Cl)([CH:22]([CH3:24])[CH3:23])[CH:19]([CH3:21])[CH3:20])([CH3:17])[CH3:16]>>[CH2:13]([N:3]([CH2:1][CH3:2])[C:4](=[O:12])[C:5]1[C:10]([Si:18]([CH:22]([CH3:24])[CH3:23])([CH:19]([CH3:21])[CH3:20])[CH:15]([CH3:17])[CH3:16])=[CH:9][CH:8]=[CH:7][C:6]=1[Cl:11])[CH3:14]

참가 물질

3

반응물 2

HCID 825662-Chloro-N,N-diethylbenzamideHCID 139400Triisopropylsilyl chloride

생성물 1

HCID 18630226n,n-Diethyl-2-chloro-6-[tris(1-methylethyl)silyl]benzamide

실험 절차

The title compound was prepared according to General Method A from the compound of Example e and 1.1 eq triisopropylsilyl chloride. Purification by HPLC using 1:19 ethyl acetate/hexanes gave 5.5 g of the desired product as of a clear oil, a 75% yield.

후처리

  1. customThe title compound was prepared
  2. customPurification by HPLC

출처 및 근거

ORD 기록
ord-f98a978f36cf430589d464139686e700
출처 데이터셋
uspto-grants-2000_10
특허 번호
US06133252

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