Carbon Dioxide → 4-Bromo-3-thenoic acid
반응식
Br[C:2]1[C:6]([Br:7])=[CH:5][S:4][CH:3]=1.[Li]C(C)(C)C.[C:13](=[O:15])=[O:14]>CCOCC.CCCCC>[Br:7][C:6]1[C:2]([C:13]([OH:15])=[O:14])=[CH:3][S:4][CH:5]=1참가 물질
6
반응 조건
- 온도
- -78 °C
실험 절차
To a solution of 3,4-dibromothiophene (15 g, 62 mmol) in 80 mL ether under a positive nitrogen atmosphere was added dropwise 75 mL 1.7M t-BuLi in pentane at below -73° C. and the resulting reaction solution was stirred at -78° C. for 0.5 h. After that, the ether solution was poured into dry ice and extracted with water. The aq solution was washed with ether and then acidified with concentrated HCl. The solid was filtered and air-dried to give 9 g of 4-bromo-3-thiophenecarboxylic acid, yield 70.3%.
후처리
- customthe resulting reaction solution
- extractionextracted with water
- washThe aq solution was washed with ether
- filtrationThe solid was filtered
- customair-dried
출처 및 근거
- ORD 기록
- ord-6212e6e68c5b487ea0df8610456e50d7
- 출처 데이터셋
- uspto-grants-2000_10
- 특허 번호
- US06133252
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