Sodium Hydroxide → 2-Chloro-1,3-thiazole-4-carboxylic acid

HRID 368686노트

반응식

HRID 368686 반응식
[OH-].[Na+].C([O:5][C:6]([C:8]1[N:9]=[C:10]([Cl:13])[S:11][CH:12]=1)=[O:7])C>C(O)C>[Cl:13][C:10]1[S:11][CH:12]=[C:8]([C:6]([OH:7])=[O:5])[N:9]=1

참가 물질

4

반응물 2

HCID 14798Sodium HydroxideHCID 13106141Ethyl 2-chlorothiazole-4-carboxylate

생성물 1

HCID 218030262-Chloro-1,3-thiazole-4-carboxylic acid수율 61.1%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

A mixture of NaOH (1.9 g, 47.5 mmol) and ethyl-2-chloro-4-thiazolecarboxylate (7.6 g, 40 mmol) in 100 mL absolute ethanol was stirred at RT for 4 h. After that, ethanol was removed in vacuo and the residue was dissolved in water. The aq layer was washed with ether and then acidified with conc HCl. The solid was filtered and air dried to give 4 g of 2-chloro-4-thiazolecarboxylic acid.

후처리

  1. customAfter that, ethanol was removed in vacuo
  2. dissolutionthe residue was dissolved in water
  3. washThe aq layer was washed with ether
  4. filtrationThe solid was filtered
  5. customair dried

출처 및 근거

ORD 기록
ord-f59266bf3c414010b3d766565c3ded01
출처 데이터셋
uspto-grants-2000_10
특허 번호
US06133252

반응 노트

불러오는 중…