Sodium Hydroxide → 1-Methyl-1H-pyrazole-4-carboxylic acid

HRID 368693노트

반응식

HRID 368693 반응식
[CH3:1][N:2]1[CH:6]=[C:5]([C:7]([O:9]CC)=[O:8])[CH:4]=[N:3]1.[OH-].[Na+]>C(O)C>[CH3:1][N:2]1[CH:6]=[C:5]([C:7]([OH:9])=[O:8])[CH:4]=[N:3]1

참가 물질

4

반응물 2

HCID 14798Sodium HydroxideHCID 11116265ethyl 1-methyl-1H-pyrazole-4-carboxylate

생성물 1

HCID 6431601-Methyl-1H-pyrazole-4-carboxylic acid수율 86%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

A solution of ethyl 1-methyl-1H-pyrazole-4-carboxylate (20.2 g, 131 mmol) and NaOH (6.3 g, 158 mmol) in 200 mL absolute ethanol was refluxed for 2 h and stirring was continued at RT for 18 h. After that, the solvent was removed in vacuo. The residue was dissolved in water. The aq solution was washed with ether and acidified with concentrated HCl. The solid was filtered, washed with water and air-dried to give 14.2 g of 1-methyl-1H-pyrazole-4-carboxylic acid in 86% yield.

후처리

  1. customAfter that, the solvent was removed in vacuo
  2. dissolutionThe residue was dissolved in water
  3. washThe aq solution was washed with ether
  4. filtrationThe solid was filtered
  5. washwashed with water
  6. customair-dried

출처 및 근거

ORD 기록
ord-678b8f3e661843e1a2cc3f135a8dd846
출처 데이터셋
uspto-grants-2000_10
특허 번호
US06133252

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