Sodium Hydroxide → 4-(4H-1,2,4-triazol-4-yl)benzoic acid
반응식
[OH-].[Na+].[N:3]1[N:4]=[CH:5][N:6]([C:8]2[CH:18]=[CH:17][C:11]([C:12]([O:14]CC)=[O:13])=[CH:10][CH:9]=2)[CH:7]=1>C(O)C>[N:3]1[N:4]=[CH:5][N:6]([C:8]2[CH:9]=[CH:10][C:11]([C:12]([OH:14])=[O:13])=[CH:17][CH:18]=2)[CH:7]=1참가 물질
4
반응 조건
- 온도
- 55 °C
실험 절차
5.5 ml of a 5 N aqueous sodium hydroxide solution was added to a solution of 1.2 g of ethyl 4-(1,2,4-triazol-4-yl)benzoate in 15 ml of ethanol. The mixture was stirred at 50-60° C. for 1 hour. The reaction mixture was concentrated under reduced pressure. To the residue was added ice water. The mixture was made acidic with acetic acid. The resulting crystals were collected by filtration, water-washed, and dried to obtain 0.95 g of 4-(1,2,4-triazol-4-yl)benzoic acid as a white powder. Melting point: 300° C. or above.
후처리
- concentrationThe reaction mixture was concentrated under reduced pressure
- additionTo the residue was added ice water
- filtrationThe resulting crystals were collected by filtration, water-
- washwashed
- customdried
출처 및 근거
- ORD 기록
- ord-4641222792614521b6e25879188d3357
- 출처 데이터셋
- uspto-grants-2000_10
- 특허 번호
- US06136826
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