Dicyclohexylcarbodiimide → N,N'-Dicyclohexylurea

HRID 369554노트

반응식

HRID 369554 반응식
CCCCCCCCCCCCCCCC(OC[C@@H](OC(CCCCCCCCCCCCCCC)=O)COC(CCC(O)=O)=O)=[O:17].ON1C(=O)CCC1=O.[CH2:56]1[CH2:61][CH2:60][CH:59]([N:62]=[C:63]=[N:64][CH:65]2[CH2:70][CH2:69][CH2:68][CH2:67][CH2:66]2)[CH2:58][CH2:57]1>CN(C1C=CN=CC=1)C.C(#N)C>[C:63]([NH:62][CH:59]1[CH2:58][CH2:57][CH2:56][CH2:61][CH2:60]1)([NH:64][CH:65]1[CH2:70][CH2:69][CH2:68][CH2:67][CH2:66]1)=[O:17]

참가 물질

6

반응물 3

HCID 10868DicyclohexylcarbodiimideHCID 80170N-HydroxysuccinimideHCID 1300201,2-Dipalmitoyl-3-succinylglycerol

생성물 1

HCID 4277N,N'-Dicyclohexylurea

시약·촉매·용매 2

HCID 142844-(Dimethylamino)pyridine촉매HCID 6342Acetonitrile용매2회

실험 절차

To a cooled (0 to 5° C.) solution of 1,2-dipalmitoyl-sn-glycero-3-succinate (66.8 mg), N-hydroxy-succinimide (11.5 mg), DMAP (2 mg) and acetonitrile (40 mL) in a 100 mL round bottom flask was added dropwise a solution of DCC (20.6 mg) in acetonitrile (10 mL). The resulting mixture was stirred for 5 hours. The solid material which formed during the reaction (dicyclohexylurea) was removed by filtration and the filtrate was concentrated in vacuo to yield 78 mg of N-DPGS-succinimide as a white product.

출처 및 근거

ORD 기록
ord-2bfd3ef9e3c94af4b8d6f926690cf0b2
출처 데이터셋
uspto-grants-2000_10
특허 번호
US06139819

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