1,2,3,4-Tetrahydroquinoline → 4-(1,2,3,4-Tetrahydroquinolin-1-yl)-6-(4-nitro-phenyl)-7H-pyrrolo[2,3-d]-pyrimidine

HRID 369714

반응식

HRID 369714 반응식
Cl[C:2]1[C:3]2[CH:10]=[C:9]([C:11]3[CH:16]=[CH:15][C:14]([N+:17]([O-:19])=[O:18])=[CH:13][CH:12]=3)[NH:8][C:4]=2[N:5]=[CH:6][N:7]=1.[NH:20]1[C:29]2[C:24](=[CH:25][CH:26]=[CH:27][CH:28]=2)[CH2:23][CH2:22][CH2:21]1>C1(C)C=CC=CC=1.CC(C)=O>[N:20]1([C:2]2[C:3]3[CH:10]=[C:9]([C:11]4[CH:16]=[CH:15][C:14]([N+:17]([O-:19])=[O:18])=[CH:13][CH:12]=4)[NH:8][C:4]=3[N:5]=[CH:6][N:7]=2)[C:29]2[C:24](=[CH:25][CH:26]=[CH:27][CH:28]=2)[CH2:23][CH2:22][CH2:21]1

참가 물질

4

반응물 2

HCID 694601,2,3,4-TetrahydroquinolineHCID 212626054-Chloro-6-(4-nitrophenyl)-7H-pyrrolo[2,3-d]pyrimidine

생성물 1

HCID 232824674-(1,2,3,4-Tetrahydroquinolin-1-yl)-6-(4-nitro-phenyl)-7H-pyrrolo[2,3-d]-pyrimidine

시약·촉매·용매 1

HCID 20247278Toluene acetone용매

실험 절차

This product is prepared in a manner analogous to that described in Example 6 from 4-chloro-6-(4-nitro-phenyl)-7H-pyrrolo[2,3-d]pyrimidine and 1,2,3,4-tetrahydroquinoline (2.1 equivalents). FAB-MS: (M+H)+ =372 (corresponds to C21H17N5O2); Rf value (toluene-acetone--4:6)=0.36.

후처리

  1. customThis product is prepared in a manner analogous to

출처 및 근거

ORD 기록
ord-9289d9a114744dd7accf6a10d1f409e5
출처 데이터셋
uspto-grants-2000_10
특허 번호
US06140317

연결된 노트

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