4-(1,2,3,4-Tetrahydroquinolin-1-yl)-6-(4-nitro-phenyl)-7H-pyrrolo[2,3-d]-pyrimidine → 4-(1,2,3,4-Tetrahydroquinolin-1-yl)-6-(4amino-phenyl)-7H-pyrrolo[2.3-d]-pyrimidine

HRID 369715

반응식

HRID 369715 반응식
[N:1]1([C:11]2[C:12]3[CH:19]=[C:18]([C:20]4[CH:25]=[CH:24][C:23]([N+:26]([O-])=O)=[CH:22][CH:21]=4)[NH:17][C:13]=3[N:14]=[CH:15][N:16]=2)[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH2:4][CH2:3][CH2:2]1>[Ni].C1(C)C=CC=CC=1.CC(C)=O>[N:1]1([C:11]2[C:12]3[CH:19]=[C:18]([C:20]4[CH:21]=[CH:22][C:23]([NH2:26])=[CH:24][CH:25]=4)[NH:17][C:13]=3[N:14]=[CH:15][N:16]=2)[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH2:4][CH2:3][CH2:2]1

참가 물질

4

반응물 1

HCID 232824674-(1,2,3,4-Tetrahydroquinolin-1-yl)-6-(4-nitro-phenyl)-7H-pyrrolo[2,3-d]-pyrimidine

생성물 1

HCID 98628314-(1,2,3,4-Tetrahydroquinolin-1-yl)-6-(4amino-phenyl)-7H-pyrrolo[2.3-d]-pyrimidine

시약·촉매·용매 2

HCID 935Nickel촉매HCID 20247278Toluene acetone용매

실험 절차

This product is obtained in a manner analogous to that described in Example 7 by hydrogenation of 4-(1,2,3,4-tetrahydroquinolin-1-yl)-6-(4-nitro-phenyl)-7H-pyrrolo[2,3-d]-pyrimidine (Example 10) with Raney nickel. M.p. 243-245° C.; FAB-MS: (M+H)+ =342 (corresponds to C21H19N5); Rf value (toluene-acetone--4:6)=0.25.

후처리

  1. customThis product is obtained in a manner analogous to

출처 및 근거

ORD 기록
ord-b5fecb1b1a8d434d917ad74f33cfe993
출처 데이터셋
uspto-grants-2000_10
특허 번호
US06140317

연결된 노트

불러오는 중…