Bromomethyl 2-methoxyphenyl ketone → 2-Amino-3-ethoxycarbonyl-5-(2-methoxy-phenyl)-1H-pyrrole

HRID 369845

반응식

HRID 369845 반응식
Cl.[CH2:2]([O:4][C:5](=[O:10])[CH2:6][C:7](=[NH:9])[NH2:8])[CH3:3].C([O-])C.[Na+].Br[CH2:16][C:17]([C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][C:20]=1[O:25][CH3:26])=O>C(O)C>[NH2:9][C:7]1[NH:8][C:17]([C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][C:20]=2[O:25][CH3:26])=[CH:16][C:6]=1[C:5]([O:4][CH2:2][CH3:3])=[O:10]

참가 물질

5

반응물 3

HCID 123440Bromomethyl 2-methoxyphenyl ketoneHCID 2723922Sodium ethoxideHCID 15555354Ethyl 2-carbamimidoylacetate hydrochloride

생성물 1

HCID 232826992-Amino-3-ethoxycarbonyl-5-(2-methoxy-phenyl)-1H-pyrrole

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

Analogously to Step 8.1, 14.5 g (87 mmol) of 2-amidino-acetic acid ethyl ester hydrochloride in 150 ml of abs. ethanol are reacted with 5.9 g (87 mmol) of sodium ethanolate and 10.3 g (44 mmol) of 2-bromo-1-(2-methoxy-phenyl)-ethan-1-one (2-bromo-2'-methoxy-acetophenone; Aldrich; Milwaukee/USA) to form the title compound; m.p.: 128° C.; TLC-Rf =0.25 (hexane/ethyl acetate [2:1]).

출처 및 근거

ORD 기록
ord-2a49f028cf6f4743b9ad849985078b6a
출처 데이터셋
uspto-grants-2000_10
특허 번호
US06140332

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