Methyl 4-(hydroxymethyl)benzoate → (E)-3-[2-n-Propyl-1-{(4-carboxyphenyl)methyl}-1h-imidazol-5-yl]-2-(2-thienyl)methyl-2-propenoic Acid
반응식
Cl.COC.[C:5]([C:9]1[CH:16]=[CH:15][C:12]([CH2:13]O)=[CH:11][CH:10]=1)([O:7]C)=[O:6].[CH2:17]([C:21]1[N:22](CC2C=CC=CC=2Cl)[C:23](/[CH:26]=[C:27](\[CH2:31][C:32]2[S:33][CH:34]=[CH:35][CH:36]=2)/[C:28]([OH:30])=[O:29])=[CH:24][N:25]=1)[CH2:18][CH2:19]C>>[CH2:17]([C:21]1[N:22]([CH2:13][C:12]2[CH:15]=[CH:16][C:9]([C:5]([OH:7])=[O:6])=[CH:10][CH:11]=2)[C:23](/[CH:26]=[C:27](\[CH2:31][C:32]2[S:33][CH:34]=[CH:35][CH:36]=2)/[C:28]([OH:30])=[O:29])=[CH:24][N:25]=1)[CH2:18][CH3:19]참가 물질
4
반응물 3
생성물 1
실험 절차
The title compound was prepared using the procedure of Example 1 replacing valermamidine methyl ether hydrochloride with butyramidine methyl ether hydrochloride and replacing 2-chlorbenzyl alcohol with 4-carbomethoxybenzyl alcohol; mp 250° C. (d).