5-Chloro-2-nitrobenzoic acid → 5-Chloro-2-nitrobenzoyl chloride

HRID 370069

반응식

HRID 370069 반응식
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([N+:11]([O-:13])=[O:12])=[C:6]([CH:10]=1)[C:7](O)=[O:8].C(Cl)(=O)C([Cl:17])=O>C(Cl)Cl.CN(C=O)C>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([N+:11]([O-:13])=[O:12])=[C:6]([CH:10]=1)[C:7]([Cl:17])=[O:8]

참가 물질

5

반응물 2

HCID 172865-Chloro-2-nitrobenzoic acidHCID 65578Oxalyl chloride

생성물 1

HCID 27236855-Chloro-2-nitrobenzoyl chloride수율 104.5%

시약·촉매·용매 2

HCID 6228Dimethylformamide촉매HCID 6344Dichloromethane용매

실험 절차

To a suspension of 5-chloro-2-nitrobenzoic acid (21 g, 100 mmol) in dry methylene chloride (200 mL) at 0° C. were added several drops of DMF, followed by oxalyl chloride (13 mL, 150 mmol). The reaction was warmed to ambient temperature. After 16 hours the solvents were removed and the viscous oil dried in vacuo to afford 23 g (quantitative yield) of 5-chloro-2-nitrobenzoyl chloride; NMR (CDCl3) 8.1 (d, 1), 7.7 (m, 2) ppm.

후처리

  1. customAfter 16 hours the solvents were removed
  2. customthe viscous oil dried in vacuo

출처 및 근거

ORD 기록
ord-334ab236062a4121888a04ebcb61115d
출처 데이터셋
uspto-grants-2000_10
특허 번호
US06140351

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