Sodium Hydroxide → 3-Chloro-5-methylthiophene-2-carboxylic acid
반응식
C[O:2][C:3]([C:5]1[S:6][C:7]([CH3:11])=[CH:8][C:9]=1[Cl:10])=[O:4].[OH-].[Na+]>C(O)C>[C:3]([C:5]1[S:6][C:7]([CH3:11])=[CH:8][C:9]=1[Cl:10])([OH:4])=[O:2]참가 물질
4
실험 절차
To a solution of 2-methoxycarbonyl-3-chloro-5-methylthiophene (1.3 g, 6.8 mmol) in ethanol (16 mL) was added aqueous sodium hydroxide (1 N, 16 mL, 16 mmol) and the mixture stirred at ambient temperature. After 3 hours the mixture was concentrated of all volatiles in vacuo. The residual solid was dissolved in water (60 mL), acidified with 1 N HCl and the solid collected by filtration to afford 1.2 g (95% yield) of 2-carboxy-3-chloro-5-methylthiophene as a white solid; NMR (CDCl3) 6.8 (s, 1), 2.5 (s, 3) ppm.
후처리
- concentrationAfter 3 hours the mixture was concentrated of all volatiles in vacuo
- dissolutionThe residual solid was dissolved in water (60 mL)
- filtrationthe solid collected by filtration
출처 및 근거
- ORD 기록
- ord-65367322375f44d6ae1d5eaadbee0047
- 출처 데이터셋
- uspto-grants-2000_10
- 특허 번호
- US06140351
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