Hydrochloric Acid → 2-(4-Benzyl-1-piperazinyl)ethoxyacetic acid dihydrochloride

HRID 370287노트

반응식

HRID 370287 반응식
[CH2:1]([N:8]1[CH2:13][CH2:12][N:11]([CH2:14][CH2:15][O:16][CH2:17][C:18](N)=[O:19])[CH2:10][CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[ClH:21].[OH2:22]>CC(C)=O>[ClH:21].[ClH:21].[CH2:1]([N:8]1[CH2:13][CH2:12][N:11]([CH2:14][CH2:15][O:16][CH2:17][C:18]([OH:19])=[O:22])[CH2:10][CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 962Water2회HCID 211883762-(4-Benzyl-1-piperazinyl)ethoxyacetamide

생성물 1

HCID 702370862-(4-Benzyl-1-piperazinyl)ethoxyacetic acid dihydrochloride

시약·촉매·용매 1

HCID 180Acetone용매

반응 조건

온도
60 °C

실험 절차

III.1.A. 13.9 g (0.05 mol) of 2-(4-benzyl-1-piperazinyl)ethoxyacetamide are dissolved in 15 ml of water in a 100 ml three-necked round-bottomed flask fitted with a water-cooled condenser and a mechanical stirrer. 31 ml (0.375 mol) of aqueous 37% hydrochloric acid solution are added. The mixture is heated at 60° C. for 1 hour. The water is removed on a rotary evaporator under reduced pressure at 60° C. The white solid obtained is taken up in 75 ml of acetone and is stirred for 1 hour at room temperature. The mixture is filtered and 19.7 g of 2-(4-benzyl-1-piperazinyl)ethoxyacetic acid dihydrochloride are obtained in the form of white crystals.

후처리

  1. temperaturecooled condenser and a mechanical stirrer
  2. customThe water is removed on a rotary evaporator under reduced pressure at 60° C
  3. customThe white solid obtained
  4. filtrationThe mixture is filtered

출처 및 근거

ORD 기록
ord-6b8c5b0072c7451f83a5b98cad8532aa
출처 데이터셋
uspto-grants-2000_10
특허 번호
US06140501

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