Propargyl alcohol → N-Desethyloxybutynin, (S)-
반응식
C1(C(C2C=CC=CC=2)(O)C(O)=O)CCCCC1.[CH3:18][CH2:19][N:20]([CH2:23][C:24]#[C:25][CH2:26][O:27][C:28]([C@:30]([OH:43])([C:37]1[CH:42]=[CH:41][CH:40]=[CH:39][CH:38]=1)[CH:31]1[CH2:36][CH2:35][CH2:34][CH2:33][CH2:32]1)=[O:29])CC.C(OC(Cl)=O)C(C)C.C(O)C#C.C(N(C(C)C#CO)CC1C=CC(OC)=CC=1)C.C1(C(C2CCCCC2)(O)C(OC#CCCN(CC)CC2C=CC(OC)=CC=2)=O)C=CC=CC=1.C(Cl)(=O)OC(Cl)C>>[C:31]1([C@:30]([CH:37]2[CH2:38][CH2:39][CH2:40][CH2:41][CH2:42]2)([OH:43])[C:28]([O:27][CH2:26][C:25]#[C:24][CH2:23][NH:20][CH2:19][CH3:18])=[O:29])[CH:32]=[CH:33][CH:34]=[CH:35][CH:36]=1참가 물질
8
반응물 7
생성물 1
실험 절차
The method according to claim 1, wherein said single enantiomer of cyclohexylphenyl glycolic acid is the (S) enantiomer, said alkyl chloroformate is isobutylchloroformate, said sidechain propargyl alcohol derivative of formula (III) is N-ethyl-N-(4-methoxybenzyl)aminobutynol, and said single enantiomer of structure (II) is N-ethyl-N-(4-methoxybenzyl)aminobutynyl phenylcyclohexyl-glycolate, which is treated with α-chloroethyl carbonochloridate to provide (S)-4-ethylamino-2-butynyl phenylcyclohexylglycolate.
출처 및 근거
- ORD 기록
- ord-11bf3b40865d45ab89832788d86873e8
- 출처 데이터셋
- uspto-grants-2000_10
- 특허 번호
- US06140529
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