Potassium Carbonate → Methyl (4-allylthio-3-ethylazetidin-2-on-1-yl)acetate

HRID 370508노트

반응식

HRID 370508 반응식
[CH2:1]([S:4][CH:5]1[NH:8][C:7](=[O:9])[CH:6]1[CH2:10][CH3:11])[CH:2]=[CH2:3].Br[CH2:13][C:14]([O:16][CH3:17])=[O:15].C(=O)([O-])[O-].[K+].[K+]>CN(C)C=O>[CH3:17][O:16][C:14](=[O:15])[CH2:13][N:8]1[CH:5]([S:4][CH2:1][CH:2]=[CH2:3])[CH:6]([CH2:10][CH3:11])[C:7]1=[O:9]

참가 물질

5

반응물 3

HCID 11430Potassium CarbonateHCID 60984Methyl bromoacetateHCID 131064924-Allylthio-3-ethylazetidinone

생성물 1

HCID 13106494Methyl (4-allylthio-3-ethylazetidin-2-on-1-yl)acetate

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

To a solution of 2.34 g of 4-allylthio-3-ethylazetidinone in 20 ml of redistilled dimethylformamide were added 1.37 ml of methyl bromoacetate and 4.16 g of ground potassium carbonate. The solution was stirred overnight then filtered through a pad of Hyflo, (Hyflo being a Trade Mark), poured into 75 ml of water, and extracted five times with ethyl acetate. The combined organic extracts were washed with water, dried over magnesium sulphate, and evaporated in vacuo to give the title compound. (Yield 3 g)

후처리

  1. filtrationthen filtered through a pad of Hyflo
  2. additionpoured into 75 ml of water
  3. extractionextracted five times with ethyl acetate
  4. washThe combined organic extracts were washed with water
  5. dry with materialdried over magnesium sulphate
  6. customevaporated in vacuo

출처 및 근거

ORD 기록
ord-2d84188b4a56427bb449539e0dfcdc04
출처 데이터셋
uspto-grants-1985_07
특허 번호
US04526718

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