Methanethiol → Ametryn

HRID 370611

반응식

HRID 370611 반응식
[Na].[CH3:2][SH:3].[CH3:4][CH2:5][NH:6][C:7]1[N:12]=[C:11](Cl)[N:10]=[C:9]([NH:14][CH:15]([CH3:17])[CH3:16])[N:8]=1>CO>[CH3:2][S:3][C:11]1[N:10]=[C:9]([NH:14][CH:15]([CH3:17])[CH3:16])[N:8]=[C:7]([NH:6][CH2:5][CH3:4])[N:12]=1

참가 물질

5

반응물 3

HCID 878MethanethiolHCID 2256AtrazineHCID 5360545Sodium

생성물 1

HCID 13263Ametryn

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

1 g of sodium was added to 100 ml of dry methanol. The solution was allowed to cool to room temperature, 12 g of methanethiol was added, then 4.5 g atrazine, and the mixture was refluxed for 2 hours. The solvent was evaporated, the residue was dissolved in water, and the solution was extracted with ether. The extract phase was dried (MgSO4) and the solvent was evaporated. The residue was dissolved in a minimum amount of boiling hexane. The solution was cooled and the solid product was collected and dried to give 2-(methylthio)-4-(1-methylethylamino)-6-(ethylamino)-1,3,5-triazine (15A) (Ametryne).

후처리

  1. customThe solvent was evaporated
  2. dissolutionthe residue was dissolved in water
  3. extractionthe solution was extracted with ether
  4. dry with materialThe extract phase was dried (MgSO4)
  5. customthe solvent was evaporated
  6. dissolutionThe residue was dissolved in a minimum amount of boiling hexane
  7. temperatureThe solution was cooled
  8. customthe solid product was collected
  9. customdried

출처 및 근거

ORD 기록
ord-cbe7ab5bfd714a279eaa03515efbabb1
출처 데이터셋
uspto-grants-1985_07
특허 번호
US04528027

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