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Acetone → 2-Amino-9-(2-deoxy-2-fluoro-beta-D-ribofuranosyl)-9H-purine bis hydrochloride

HRID 37086
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인쇄 미리보기

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HRID 37086 반응식
[NH2:1][C:2]1[N:10]=[C:9]2[C:5]([N:6]=[CH:7][N:8]2[C@@H:11]2[O:16][C@H:15]([CH2:17][OH:18])[C@@H:13]([OH:14])[C@H:12]2[F:19])=[CH:4][N:3]=1.C(O)(C)C.[ClH:24].CC(C)=O>CO>[ClH:24].[ClH:24].[NH2:1][C:2]1[N:10]=[C:9]2[C:5]([N:6]=[CH:7][N:8]2[C@@H:11]2[O:16][C@H:15]([CH2:17][OH:18])[C@@H:13]([OH:14])[C@H:12]2[F:19])=[CH:4][N:3]=1
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

6

반응물 4

HCID 180AcetoneHCID 313Hydrochloric AcidHCID 3776IsopropanolHCID 10355712(2R,3R,4R,5R)-5-(2-Amino-9H-purin-9-yl)-4-fluoro-2-(hydroxymethyl)tetrahydrofuran-3-ol

생성물 1

HCID 867486882-Amino-9-(2-deoxy-2-fluoro-beta-D-ribofuranosyl)-9H-purine bis hydrochloride

시약·촉매·용매 1

HCID 887
Methanol
용매

실험 절차

To a solution of 2-amino-9-(2-deoxy-2-fluoro-β-D-ribofuranosyl)-9H-purine (300 mg 1.11 mmol) in MeOH (20 ml) was added isopropanol (2.5 ml) previously saturated with hydrochloride (HCL) gas. Acetone (15 ml) was added and the solution evaporated to almost dryness under vacuum at room temperature. Trituration with ethyl acetate (15 ml) produced a white solid which was filtered and washed with ether.

후처리

  1. customthe solution evaporated to almost dryness under vacuum at room temperature
  2. customTrituration with ethyl acetate (15 ml) produced a white solid which
  3. filtrationwas filtered
  4. washwashed with ether

출처 및 근거

ORD 기록
ord-28097341039e4cbe8dc7d52b6100e3d6
출처 데이터셋
uspto-grants-1995_05
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US05420115

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