Ethanol → HCID 20262414, 화합물

HRID 371104노트

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HRID 371104 반응식
[NH:1]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[C:3]([CH:10]2[CH2:15][CH2:14][N:13]([CH2:16][CH2:17][C:18]3[C:23](=[O:24])[N:22]4[C:25]([CH3:28])=[CH:26][S:27][C:21]4=[N:20][C:19]=3[CH3:29])[CH2:12][CH2:11]2)=[CH:2]1.C(O)C.[P:33](=[O:37])([OH:36])([OH:35])[OH:34]>O>[P:33]([OH:37])([OH:36])([OH:35])=[O:34].[NH:1]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[C:3]([CH:10]2[CH2:15][CH2:14][N:13]([CH2:16][CH2:17][C:18]3[C:23](=[O:24])[N:22]4[C:25]([CH3:28])=[CH:26][S:27][C:21]4=[N:20][C:19]=3[CH3:29])[CH2:12][CH2:11]2)=[CH:2]1

참가 물질

5

반응물 3

HCID 702EthanolHCID 1004Phosphoric AcidHCID 30861076-(2-(4-(1H-Indol-3-yl)piperidin-1-yl)ethyl)-3,7-dimethyl-5H-thiazolo(3,2-a)pyrimidin-5-one

생성물 1

HCID 20262414HCID 20262414, 화합물수율 80%

시약·촉매·용매 1

HCID 962Water용매

실험 절차

A stirred and warm suspension of 4 parts of 6-[2-[4-(1H-indol-3-yl)-1-piperidinyl]ethyl]-3,7-dimethyl-5H-thiazolo[3,2-a]pyrimidin-5-one in 80 parts of ethanol was acidified with phosphoric acid. 60 parts of water were added and the whole was boiled. The undissolved material was filtered off and the filtrate was allowed to crystallize. The product was filtered off and dried, yielding 4.5 parts (80%) of 6-[2-[4-(1H-indol-3-yl)-1-piperidinyl]ethyl]-3,7-dimethyl-5H-thiazolo[3,2-a]pyrimidin-5-one phosphate (2:3) monohydrate; mp. 214.4° C. (compound 28).

후처리

  1. temperaturewarm
  2. filtrationThe undissolved material was filtered off
  3. customto crystallize
  4. filtrationThe product was filtered off
  5. customdried

출처 및 근거

ORD 기록
ord-d9a01389ac6a4d459c90fdd5f5812f19
출처 데이터셋
uspto-grants-1985_07
특허 번호
US04529727

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