Chloromethyl(4-phenylphenyl)divinylsilane → Divinyl(1H-imidazol-1-ylmethyl)(4-phenylphenyl)silane

HRID 371315노트

반응식

HRID 371315 반응식
Cl[CH2:2][Si:3]([C:8]1[CH:13]=[CH:12][C:11]([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)=[CH:10][CH:9]=1)([CH:6]=[CH2:7])[CH:4]=[CH2:5].[NH:20]1[CH:24]=[CH:23][N:22]=[CH:21]1.[K]>C1(C)C=CC=CC=1.[Br-].C([N+](CCCC)(CCCC)CCCC)CCC>[CH:4]([Si:3]([CH:6]=[CH2:7])([CH2:2][N:20]1[CH:24]=[CH:23][N:22]=[CH:21]1)[C:8]1[CH:13]=[CH:12][C:11]([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)=[CH:10][CH:9]=1)=[CH2:5]

참가 물질

5

반응물 2

HCID 20273719Chloromethyl(4-phenylphenyl)divinylsilaneHCID 67086713Potassium imidazole

생성물 1

HCID 13489959Divinyl(1H-imidazol-1-ylmethyl)(4-phenylphenyl)silane

시약·촉매·용매 2

HCID 74236Tetrabutylammonium Bromide촉매HCID 1140Toluene용매

실험 절차

To a solution of 1.14 g (0.004 mol) of chloromethyl(4-phenylphenyl)divinylsilane in 10 ml of toluene is added 0.54 g (0.005 mol) of potassium imidazole and 0.05 g of tetrabutylammonium bromide. The mixture is refluxed under nitrogen for two days, cooled, diluted with ether-hexanes, and washed with water and brine. Removal of solvent gives an oil which is purified by silica gel chromatography, eluting with 9:1 dichloromethane-ether, to give the title compound.

후처리

  1. temperatureThe mixture is refluxed under nitrogen for two days
  2. temperaturecooled
  3. washwashed with water and brine
  4. customRemoval of solvent
  5. customgives an oil which
  6. customis purified by silica gel chromatography
  7. washeluting with 9:1 dichloromethane-ether

출처 및 근거

ORD 기록
ord-9f4c7b118be645d997e352a54cb7baa0
출처 데이터셋
uspto-grants-1985_07
특허 번호
US04530922

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