Isobutyl chloride → (Z)-1,1,1-trifluoro-4-phenyl-3-butene-2-ol

HRID 371367

반응식

HRID 371367 반응식
C([Mg]Cl)C(C)C.C(Cl)C(C)C.[Mg].[F:13][C:14]([F:26])([F:25])[CH:15]([OH:24])[C:16]#[C:17][C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1>CCOCC.[CH-]1[C-]=[C-][C-]=[C-]1.[CH-]1[C-]=[C-][C-]=[C-]1.Cl[Ti]Cl>[F:13][C:14]([F:25])([F:26])[CH:15]([OH:24])/[CH:16]=[CH:17]\[C:18]1[CH:19]=[CH:20][CH:21]=[CH:22][CH:23]=1

참가 물질

7

반응물 4

HCID 10554Isobutyl chlorideHCID 5462224MagnesiumHCID 114129783-Butyn-2-ol, 1,1,1-trifluoro-4-phenyl-HCID 178418368HCID 178418368, 화합물

생성물 1

HCID 12755329(Z)-1,1,1-trifluoro-4-phenyl-3-butene-2-ol수율 53%

시약·촉매·용매 2

HCID 416358Bis(cyclopentadienyl)titanium(IV) chloride촉매HCID 3283Diethyl Ether용매

실험 절차

In an isobutylmagnesium chloride solution that was prepared by reacting isobutyl chloride (2.34 g, 25 mmol) and magnesium (0.66 g, 27 mmol) in dry ether (30 ml) at 0° C., dichlorobis(π-cyclopentadienyl)titanium (0.14 g, 0.56 mmol) and 1,1,1,-trifluoro-4-phenyl-3-butyne-2-ol (2g, 10 mmol) were slowly added at 0° C. After 1 hour agitation at the same temperature, the reaction mixture was treated by a method similar to the one in the above Examples to obtain (Z)-1,1,1-trifluoro-4-phenyl-3-butene-2-ol (b.p.: 78°-80° C./3 mmHg) at a yield of 53%. The above product gave the following analytical data:

후처리

  1. customat 0° C.

출처 및 근거

ORD 기록
ord-dc9653106666434a8f997356c245e2c9
출처 데이터셋
uspto-grants-1985_07
특허 번호
US04532020

연결된 노트

불러오는 중…