Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Pyridine → 6-Amidino-2-naphthyl 4-benzyloxycarbonylaminomethylbenzoate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Pyridine | HCID 1049 | — |
| 반응물 | Dicyclohexylcarbodiimide | HCID 10868 | — |
| 반응물 | 4-((((Benzyloxy)carbonyl)amino)methyl)benzoic acid | HCID 1479997 | — |
| 반응물 | 6-Carbamimidoylnaphthalen-2-yl methanesulfonate | HCID 13050560 | — |
| 용매 | Diethyl Ether | HCID 3283 | — |
| 생성물 | 6-Amidino-2-naphthyl 4-benzyloxycarbonylaminomethylbenzoate | HCID 13176887 | 46.9% |
반응 단계
To 50 ml of dried pyridine, were added 5.1 g of 4-benzyloxycarbonylaminomethylbenzoic acid and 4.4 g of DCC. The mixture was stirred under cooling in ice for 30 minutes, admixed with 5.0 g of 6-amidino-2-naphthol methanesulfonate and stirred for one hour under cooling in ice, then overnight at room temperature. The reaction mixture was filtered* and the filtrate was mixed with ethyl ether. The precipitate which was formed was collected by filtration and recrystallized from a DMF-ethanol mixture to obtain 3.8 g of a white powder of a white powder of 6-amidino-2-naphthyl 4-benzyloxycarbonylaminomethylbenzoate methanesulfonate.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04532255 |
| 출처 데이터셋 | uspto-grants-1985_07 |
| ORD ID | ord-9e5fc2c2395f4db097b15096d444a484 |
| 출처 메모 | uspto-grants-1985_07 |