Water → 2-Chloro-4-[(4-chlorophenyl)methyl]-6-methylphenol

HRID 371521노트

반응식

HRID 371521 반응식
[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([CH3:8])[C:3]=1[OH:9].[Cl:10][C:11]1[CH:18]=[CH:17][C:14]([CH2:15]Cl)=[CH:13][CH:12]=1.O>C(Cl)(Cl)Cl.[Cl-].[Cl-].[Zn+2]>[Cl:1][C:2]1[CH:7]=[C:6]([CH2:15][C:14]2[CH:17]=[CH:18][C:11]([Cl:10])=[CH:12][CH:13]=2)[CH:5]=[C:4]([CH3:8])[C:3]=1[OH:9]

참가 물질

6

반응물 3

HCID 962WaterHCID 68982-Chloro-6-methylphenolHCID 77231-Chloro-4-(chloromethyl)benzene

생성물 1

HCID 233194162-Chloro-4-[(4-chlorophenyl)methyl]-6-methylphenol

시약·촉매·용매 2

HCID 3007855Zincchloride촉매HCID 6212Chloroform용매

실험 절차

178.1 g (1.25 mol) 2-chloro-6-methylphenol and 80.5 g (0.5 mol) 4-chlorobenzyl chloride are dissolved in 300 ml dry chloroform. 40 g water-free, finely mortared ZnCl2 are subsequentlyadded.

출처 및 근거

ORD 기록
ord-b42a7c7a56254d26ad242311a2889111
출처 데이터셋
uspto-grants-1985_07
특허 번호
US04532367

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