Water → 4-Chloro-2-ethyl-6-{[4-(propan-2-yl)phenyl]methyl}phenol

HRID 371523노트

반응식

HRID 371523 반응식
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([OH:8])=[C:4]([CH2:9][CH3:10])[CH:3]=1.[CH:11]([C:14]1[CH:21]=[CH:20][C:17]([CH2:18]Cl)=[CH:16][CH:15]=1)([CH3:13])[CH3:12].O>C(Cl)(Cl)Cl>[Cl:1][C:2]1[CH:7]=[C:6]([CH2:18][C:17]2[CH:20]=[CH:21][C:14]([CH:11]([CH3:13])[CH3:12])=[CH:15][CH:16]=2)[C:5]([OH:8])=[C:4]([CH2:9][CH3:10])[CH:3]=1

참가 물질

5

반응물 3

HCID 962WaterHCID 293574-Chloro-2-EthylphenolHCID 749164-Isopropylbenzyl chloride

생성물 1

HCID 233194194-Chloro-2-ethyl-6-{[4-(propan-2-yl)phenyl]methyl}phenol

시약·촉매·용매 1

HCID 6212Chloroform용매

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온도
60 °C

실험 절차

117.5 g (0.75 mol) 4-chloro-2-ethylphenol are dissolved with 42.25 g (0.25 mol) 4-isopropylbenzylchloride in 200 ml chloroform. 22.5 g water-free zinc chloride are added thereto for the alkylation reaction. Already at 30° C. a powerful reaction takes place. The entire mixture is after-stirred 5-6 h at 60° C. for completion of the alkylation. After a cooling it is subsequently washed three times each with 200 ml water, and then dried across sodium sulfate, after which the solvent chloroform is driven off.

후처리

  1. customfor the alkylation reaction
  2. customAlready at 30° C. a powerful reaction
  3. washAfter a cooling it is subsequently washed three times each with 200 ml water
  4. dry with materialdried across sodium sulfate

출처 및 근거

ORD 기록
ord-fd94c07d2e76497d84a4d35ea1dcde1e
출처 데이터셋
uspto-grants-1985_07
특허 번호
US04532367

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