Hydrochloric Acid → 6-Amino-2-(trifluoromethyl)-1H-imidazo[4,5-b]pyridin-1-ol

HRID 371663노트

반응식

HRID 371663 반응식
[N+:1]([C:4]1[CH:5]=[C:6]2[N:12]([OH:13])[C:11]([C:14]([F:17])([F:16])[F:15])=[N:10][C:7]2=[N:8][CH:9]=1)([O-])=O.C(O)C.Cl.[H][H]>[Pd].O>[NH2:1][C:4]1[CH:5]=[C:6]2[N:12]([OH:13])[C:11]([C:14]([F:15])([F:17])[F:16])=[N:10][C:7]2=[N:8][CH:9]=1

참가 물질

7

반응물 4

HCID 313Hydrochloric AcidHCID 702EthanolHCID 203554946-Nitro-2-(trifluoromethyl)-1H-imidazo[4,5-b]pyridin-1-olHCID 178418361HCID 178418361, 화합물

생성물 1

HCID 203554676-Amino-2-(trifluoromethyl)-1H-imidazo[4,5-b]pyridin-1-ol

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 962Water용매

실험 절차

6-Nitro-1-hydroxy-2-(trifluoromethyl)-1H-imidazo(4,5-b)pyridine (4.9 grams) was mixed with 100 milliliters of ethanol and 3 milliliters of concentrated hydrochloric acid, and 1 gram of 5 percent palladium on carbon was added to the mixture. The mixture was hydrogenated to a 3 mole-equivalent uptake of hydrogen. The reaction mixture was then filtered and evaporated, yielding a gummy solid residue which was taken up in 150 milliliters of water and used directly in the reaction reported in the following example.

후처리

  1. additionwas added to the mixture
  2. filtrationThe reaction mixture was then filtered
  3. customevaporated
  4. customyielding a gummy solid residue which

출처 및 근거

ORD 기록
ord-9ee81935c37245bd9899f682e25f1938
출처 데이터셋
uspto-grants-1978_05
특허 번호
US04087432

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