Diethyl Oxalate → 1-Ethyl-2,3-piperazinedione

HRID 371686

반응식

HRID 371686 반응식
CCO[C:4]([C:6]([O:8]CC)=O)=[O:5].[CH2:11]([NH:13][CH2:14][CH2:15][NH2:16])[CH3:12]>C(O)C>[CH2:11]([N:13]1[CH2:14][CH2:15][NH:16][C:6](=[O:8])[C:4]1=[O:5])[CH3:12]

참가 물질

4

반응물 2

HCID 7268Diethyl OxalateHCID 66071N-Ethylethylenediamine

생성물 1

HCID 1088121-Ethyl-2,3-piperazinedione수율 76.1%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

Into a mixture comprising 8 g of a diethyl ester of oxalic acid and 8 ml of ethanol was dropped at room temperature 4.4 g of N-ethyl ethylenediamine. The resulting mixture was allowed to react for 3 hours, and then heated to remove the ethanol. Subsequently, the residue was recrystallized from 10 ml of dioxane to obtain 5.4 g of 1-ethyl-2,3-dioxo-piperazine, m.p. 124° C, yield 76.0%.

후처리

  1. customto react for 3 hours
  2. temperatureheated
  3. customto remove the ethanol
  4. customSubsequently, the residue was recrystallized from 10 ml of dioxane

출처 및 근거

ORD 기록
ord-933aa54376704b39bf9a3efd64b9693c
출처 데이터셋
uspto-grants-1978_05
특허 번호
US04087424

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