Tert-Butylamine → [(t-Butylcarbamoyl)methyl]phosphonic acid

HRID 371700

반응식

HRID 371700 반응식
[C:1]([NH2:5])([CH3:4])([CH3:3])[CH3:2].[C:6]([CH2:9][P:10](=[O:15])([O:13]C)[O:11]C)(O)=[O:7].C1(N=C=NC2CCCCC2)CCCCC1>C(Cl)Cl>[C:1]([NH:5][C:6]([CH2:9][P:10](=[O:11])([OH:15])[OH:13])=[O:7])([CH3:4])([CH3:3])[CH3:2]

참가 물질

5

반응물 3

HCID 6385Tert-ButylamineHCID 10868DicyclohexylcarbodiimideHCID 1899642-(Dimethoxyphosphoryl)acetic acid

생성물 1

HCID 22748653[(t-Butylcarbamoyl)methyl]phosphonic acid

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

Tertiary butyl amine (0.045 mole) and dimethyl (carboxymethyl)phosphonate (0.04 mole) were dissolved in 100 ml. of methylene chloride. As the solution was stirred, dicyclohexylcarbodiimide was added portionwise. The solution was stirred overnight and the mixture filtered. The filtrate was concentrated to a solid. It was recrystallized from an appropriate solvent such as methanol. m.p. 163°-5° C., yield, 61%.

후처리

  1. stirringThe solution was stirred overnight
  2. filtrationthe mixture filtered
  3. concentrationThe filtrate was concentrated to a solid
  4. customIt was recrystallized from an appropriate solvent such as methanol
  5. customm.p. 163°-5° C., yield

출처 및 근거

ORD 기록
ord-fdc5e424f1ab4d7eb193b14a80ef3588
출처 데이터셋
uspto-grants-1978_05
특허 번호
US04087522

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