Diazomethane → HCID 20356176, 화합물

HRID 371742노트

반응식

HRID 371742 반응식
[O:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[C:6]([C:8]1[N:12]2[CH2:13][CH2:14][CH:15]([C:16]([OH:18])=[O:17])[C:11]2=[CH:10][CH:9]=1)=[O:7].[N+](=[CH2:21])=[N-]>ClCCl>[O:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[C:6]([C:8]1[N:12]2[CH2:13][CH2:14][CH:15]([C:16]([O:18][CH3:21])=[O:17])[C:11]2=[CH:10][CH:9]=1)=[O:7]

참가 물질

4

반응물 2

HCID 9550DiazomethaneHCID 203560965-(Furan-2-carbonyl)-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid

생성물 1

HCID 20356176HCID 20356176, 화합물

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

A solution of 200 mg. of 5-(2-furoyl)-1,2-dihydro-3H-pyrrolo[1,2-a]pyrrole-1-carboxylic acid in 5 ml. of dichloromethane is treated with an excess of ethereal diazomethane, and the reaction mixture is maintained at room temperature for 30 minutes. The solvents and excess reagent are eliminated under reduced pressure and the residue crystallized from ethyl acetate-methanol, to yield methyl 5-(2-furoyl)-1,2-dihydro-3H-pyrrolo[1,2-a]pyrrole-1-carboxylate.

후처리

  1. customthe residue crystallized from ethyl acetate-methanol

출처 및 근거

ORD 기록
ord-2839e573a54141379294f4875d5834c4
출처 데이터셋
uspto-grants-1978_05
특허 번호
US04087539

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