Water → 19-Methoxyandrost-4-ene-3,17-dione

HRID 371815

반응식

HRID 371815 반응식
[OH:1][CH2:2][C@@:3]12[C@@H:20]3[C@H:11]([C@H:12]4[C@@:16]([CH2:18][CH2:19]3)([CH3:17])[C:15](=[O:21])[CH2:14][CH2:13]4)[CH2:10][CH2:9][C:8]1=[CH:7][C:6](=[O:22])[CH2:5][CH2:4]2.F[B-](F)(F)F.[CH3:28][O+](C)C.O>C(Cl)Cl>[CH3:28][O:1][CH2:2][C@@:3]12[C@@H:20]3[C@H:11]([C@H:12]4[C@@:16]([CH2:18][CH2:19]3)([CH3:17])[C:15](=[O:21])[CH2:14][CH2:13]4)[CH2:10][CH2:9][C:8]1=[CH:7][C:6](=[O:22])[CH2:5][CH2:4]2

참가 물질

5

반응물 3

HCID 962WaterHCID 25237919-HydroxyandrostenedioneHCID 2735153Oxonium, trimethyl-, tetrafluoroborate(1-) (1:1)

생성물 1

HCID 5415304219-Methoxyandrost-4-ene-3,17-dione

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

19-Hydroxyandrost-4-ene-3,17-dione is dissolved in methylenechloride and trimethyloxonium fluoroborate added. After stirring at room temperature for a period of two hours, water is added to the reaction mixture, the organic layer is separated, dried over magnesium sulfate and the solvent removed under vacuum. The residue is crystallized from an acetone-hexane solution to yield the desired 19-methoxyandrost-4-ene-3,17-dione.

후처리

  1. customthe organic layer is separated
  2. dry with materialdried over magnesium sulfate
  3. customthe solvent removed under vacuum
  4. customThe residue is crystallized from an acetone-hexane solution

출처 및 근거

ORD 기록
ord-375ad16dbc2f48c98abcf840ec02c66b
출처 데이터셋
uspto-grants-1978_05
특허 번호
US04087524

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