Triethylamine → 1-Methylcarbamoyl-4-(3',5'-dichlorophenyl) urazole

HRID 371986노트

반응식

HRID 371986 반응식
[Cl:1][C:2]1[CH:3]=[C:4]([N:9]2[C:13](=[O:14])[NH:12][NH:11][C:10]2=[O:15])[CH:5]=[C:6]([Cl:8])[CH:7]=1.C(N(CC)CC)C.[CH3:23][N:24]=[C:25]=[O:26]>CN(C)C=O.O>[CH3:23][NH:24][C:25]([N:12]1[C:13](=[O:14])[N:9]([C:4]2[CH:3]=[C:2]([Cl:1])[CH:7]=[C:6]([Cl:8])[CH:5]=2)[C:10](=[O:15])[NH:11]1)=[O:26]

참가 물질

6

반응물 3

HCID 8471TriethylamineHCID 12228Methyl IsocyanateHCID 187550094-(3,5-Dichlorophenyl)-1,2,4-triazolidine-3,5-dione

생성물 1

HCID 536345341-Methylcarbamoyl-4-(3',5'-dichlorophenyl) urazole

시약·촉매·용매 2

HCID 962Water용매HCID 6228Dimethylformamide용매

실험 절차

To a solution of 2.5 g of 4-(3',5'-dichlorophenyl) urazole in 10 ml of N,N-dimethylformamide were added a drop of triethylamine and, in turn, 0.8 g of methyl isocyanate dropwise at room temperature with agitation. The reaction was continued for one additional hour under the same conditions and the reaction mixture was poured in water to precipitate crystals which were filtered and recrystallized from acetoneethanol to obtain 1-methylcarbamoyl-4-(3',5'-dichlorophenyl) urazole in an amount of 2.1 g (yield being 68%).

후처리

  1. customdropwise at room temperature
  2. customto precipitate crystals which
  3. filtrationwere filtered
  4. customrecrystallized from acetoneethanol

출처 및 근거

ORD 기록
ord-7e08e28a5ddb45e792dc145ae6ac7e1e
출처 데이터셋
uspto-grants-1978_05
특허 번호
US04088767

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