Ethyl Acetate → Methyl 2-(2-chloro-4-methylphenoxy)-2-phenylacetate

HRID 37226

반응식

HRID 37226 반응식
[H-].[Na+].[Cl:3][C:4]1[CH:9]=[C:8]([CH3:10])[CH:7]=[CH:6][C:5]=1[OH:11].Br[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=1[CH2:19][C:20]([O:22][CH3:23])=[O:21].C(OCC)(=O)C>CN(C=O)C>[Cl:3][C:4]1[CH:9]=[C:8]([CH3:10])[CH:7]=[CH:6][C:5]=1[O:11][CH:19]([C:14]1[CH:15]=[CH:16][CH:17]=[CH:18][CH:13]=1)[C:20]([O:22][CH3:23])=[O:21]

참가 물질

6

반응물 4

HCID 8857Ethyl AcetateHCID 148512-Chloro-4-methylphenolHCID 24758Sodium hydrideHCID 8063364Methyl 2-(2-bromophenyl)acetate

생성물 1

HCID 19385673Methyl 2-(2-chloro-4-methylphenoxy)-2-phenylacetate수율 83.1%

시약·촉매·용매 1

HCID 6228Dimethylformamide용매2회

실험 절차

To a suspension of 0.282 g (7.04 mmol) of a 60% oil dispersion of sodium hydride in DMF was added 1.00 g (7.04 mmol) of 2-chloro-4-methylphenol and the mixture was stirred under an N2 atmosphere at room temperature. After 10 minutes, a solution of 1.94 g (8.45 mmol) of methyl 2-bromophenylacetate dissolved in 10 mL of DMF was added and the reaction was stirred an additional 1.5 hours. The reaction was then diluted into ethyl acetate, washed with water, dried (MgSO4), filtered and evaporated. The residue was purified on a silica gel flash chromatography column eluted with 4% ethyl acetate/hexane to afford 1.70 g (83%) of the title compound.

후처리

  1. additionwas added
  2. stirringthe reaction was stirred an additional 1.5 hours
  3. washwashed with water
  4. dry with materialdried (MgSO4)
  5. filtrationfiltered
  6. customevaporated
  7. customThe residue was purified on a silica gel flash chromatography column
  8. washeluted with 4% ethyl acetate/hexane

출처 및 근거

ORD 기록
ord-bd543a16374445459cca709e6c28721d
출처 데이터셋
uspto-grants-1995_05
특허 번호
US05420133

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